Summary:
- The article examines the intersection of hormonal shifts during menopause and the increased prevalence of Alzheimer’s disease in women.
- It explores the "critical window" hypothesis, which suggests that hormone replacement therapy may only provide neuroprotective benefits if administered during a specific timeframe relative to the onset of menopause.
- The research highlights the necessity of sex-specific clinical trials to better understand how estrogen depletion affects brain health and long-term cognitive outcomes.