Summary:
- This article provides a comprehensive review of the current landscape of mRNA-based therapeutics, detailing the advancements in delivery systems and the optimization of mRNA sequences.
- It explores the expanding clinical applications of mRNA technology, moving beyond prophylactic vaccines to include cancer immunotherapy, protein replacement therapies, and treatments for genetic disorders.
- The authors discuss the technical challenges remaining in the field, such as enhancing intracellular delivery efficiency and mitigating potential immunogenicity to improve the long-term safety and efficacy of these platforms.