Summary:
- Researchers at the Weizmann Institute of Science have identified a specific mechanism by which the brain's "internal clock" (circadian rhythm) regulates the liver's metabolic processes.
- The study reveals that the protein REV-ERBα acts as a critical molecular bridge, synchronizing the liver’s glucose and lipid metabolism with the body's central circadian pacemaker.
- These findings provide significant insights into how circadian disruptions contribute to metabolic disorders such as obesity and type 2 diabetes, potentially paving the way for chronotherapy-based treatments.