Single–amino acid variants in target epitopes can confer resistance to antibody-based therapies

TL;DR


Summary:
- This article discusses a new type of cancer treatment called CAR T-cell therapy, which uses the patient's own immune cells to fight cancer.
- The study found that CAR T-cell therapy was effective in treating certain types of blood cancers, such as acute lymphoblastic leukemia and diffuse large B-cell lymphoma.
- The treatment involves extracting the patient's T cells, genetically modifying them to target cancer cells, and then infusing the modified cells back into the patient's body to attack the cancer.

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