Summary:
- This article reports on the development of a new technique called "Supercritical Angle Fluorescence Microscopy" (SAFM) that can achieve super-resolution imaging of biological samples.
- SAFM utilizes the supercritical angle phenomenon to selectively excite and detect fluorophores near the sample surface, enabling nanometer-scale resolution without the need for complex sample preparation or specialized equipment.
- The authors demonstrate the capabilities of SAFM by imaging various biological structures, including mitochondria, endoplasmic reticulum, and the actin cytoskeleton, showcasing its potential for high-resolution visualization of cellular processes.